Active Security Components -
FileHippo Updater - Yes, I consider this part of security very important. Several security vulnerabilities come from outdated software. Among the most vulnerable are Adobe Reader, Flash and Shockwave. Java, Itunes, and Web Browsers are very susceptible as well. Safari and Chrome is the worst among browsers.
Microsoft Enhanced Mitigation Experience Toolkit (EMET) - Helps protect against 0-day vulnerabilities at the application layer. EMET uses DEP, SEHOP, NullPage, HeapSpray, EAF and MandatoyASLR elements to protect your PC (Windows7 only).
Comodo Internet Security
High heuristics, Sandbox enabled, Defense+ in Clean PC mode.
Immunet Protect with SPERO and ETHOS enabled, CLAMAV disabled. This is a “cloud” scanner, so all the resource usage to scan is done on their servers. Immunet was specifically developed to run alongside other AV.
Browser Security -
M86 Security addon for IE and FF. This actually performs a real-time scan (not your PC resources in use) and “scrubs” out suspicious/malicious code built into the HTML itself BEFORE it gets to you.
Keyscrambler addon for IE and FF. This prevents keyloggers from successfully capturing your information while browsing, but not your entire PC.
I also have my DNS set to use “Clearcloud” on my router. Currently, this is the most developed DNS server to help block malicious sites from reaching your machine.
Reactive Security Components - I only use these after something suspicious.
I will scan with Malwarebytes’ Anti-Malware, SuperAntiSpyware, Hitman Pro, and Norton Power Eraser.
Emergency Situation -
I will just restore my OS from an image that I backup DAILY with Windows Home Server.
Summary
Clearcloud DNS will perform a scrub, followed by M86, BEFORE anything reaches my OS. If something gets past that, EMET will mitigate the damage, then CIS and Immunet cloud scanner will find it. If they don’t, then I run my reactive scans. If all else fails or I feel insecure, I perform a restore from a recent image. Now THAT is what I call security!