Yubikey and sandbox

I’m thinking of biting the bullet and purchasing a Yubikey to better secure my online accounts. Are there any issues using a physical key plugged into a USB port on my laptop when trying to access accounts through a sandboxed browser launched via the Browsers Pane on the Comodo desktop Widget?

I’ve had issues with Comodo FW and hitmanpro alert which also has keystroke encryption.

Yikes! I also run both of those together.

Comodo’s HIPS protects the keyboard…along with a bunch of other stuff.