Will not update AV Signatures

First off, just to cover the bases, did you follow these instructions with activating the virus database

Also, do you have this version of Outpost? If so why have both it and Comodo Firewall even installed at the same time?

As for MalwareBytes is it the free version? If so then you may as well uninstall it as it could make troubleshooting easier.

Lastly, did you have any versions of CIS installed in the past?