"Unable to contact database

XP sp2
Firefox 3.5.7
latest CVE updated today
Comodo IS 3.14.130099.587

This starts popping up in an annoyingly frequent manner from time to time. It has done this a few times in the past, but today is continuous on almost all pages. to my knowledge my system has not changed except to auto-update the CVE.

FYI and any help appreciated.