Can you connect without problems when firewall is disabled (click on icon in tray->firewall->disabled)? If no, can you connect when both firewall and defense+ are disabled?
On what computer(s) CF is installed (1, 2, 3)? Why do you have 192.168.1.100/255.255.255.0 under Loopback Zone: it is supposed to be only 127.0.0.1/255.0.0.0 there.
First of all, when you shut down Comodo, it is still working. Only way to disable it is to use icon in tray to disable firewall. If problems are still with you, disable Defense+, leave firewall in disabled mode.
If you still experience issues, deactivate Defense+ permanently (under settings), leave both firewall and D+ in disabled mode, reboot computer.
If problems are still here, CF probably is not the reason of them. Though only way to find out is to uninstall it, leave Windows settings untouched and check whether problems are gone.