question regarding "protection settings"


this is a very interesting settings, although i thought, that when using the whole D+ HIPS section, all those settings are enabled anyway.

If this is not the case, which applications are typically recommended to have those extra protections enabled?
I have browsers running sandboxed, so maybe here it would be not so effective, but what else are the critical apps, where the usage of this protection would be useful? File managers? certain system apps?