Protection against ransomware.

Yes, CIS protects against Ransomware, and any other kind of Malware, through Auto-Containment & HIPS modules.

You can change CIS to ‘Proactive Security’ mode, this will enhance overall protection of all CIS components. You can also check and use the Cruelsister settings for Comodo Firewall (also valid for CIS) which will further enhance the level of protection provided.