Please be careful when you are in the Groups screen not to remove any groups.
Go to Defense+ \ Computer Security Policy \ Protected files and folders tab
Click Groups then click Add \ A New Group, type your group name (App-Exe) click apply
Scroll to bottom, right click on Add files here, click add type (path you wish) were it says Add new item click + at the end then apply \ apply \ OK
Now add this group to Protected Files and Folders you now have your protected file path click OK again.
Sorry you have go out of Computer Security Policy each time or the rule is not saved.
Go to Defence+ Rules add access to the file group (App-Exe) for the process you wish to have access.
Then go to All Applications and add this File Group (App-Exe) to Blocked Files/Folders please make sure your application rule is above the All Applications rule click OK again.