In 3.0.8.214, Image Execution seems to be broken.
I tried to run an application via a shortcut pinned in the start menu. After a minute or so, I got a windows popup warning me that the executable was corrupt. In Defense+ Events, I could see that Comodo had blocked Exporer.exe from launching the .exe.
Defense+ was in Learn Safe mode, and Image Executution Control Settings was in Normal mode. I tried turning this off (Disabled) and applying, but when I went back into the configuration, the setting had reverted to Normal.
In the end, I changed Defense+ to “Learn All” and launched the executable. I verified that this had added the .exe to the list of allowed programs for Explorer.exe