Closing the tabs that get this and relaunching doesn’t fix it. I can kill the plugin via the comodo task manager which works for awhile. Closing the browser all together and verifying all processes have ended lasts a little longer. I do not have this problem in IE8, IE9, IE10, Firefox stable and nightlies, other versions of Firefox (like icedragon) or Opera.
All drivers are up to date
All Adobe products are up to date
I have not tried setting the protectedmode flag for flash as it works fine in the other browsers mentioned above.