Error: "Windows cannot access the specified drive path or file"

I recently had a problem with trying to open any file or program that I had on my desktop. Every time I tried to open a program/file I got an error message saying "Error: “Windows cannot access the specified drive path or file”.

The only way I could get anything done was by going into Task Manager and browsing manually for a specific file or program.

After checking for Malware, it turns out once I uninstalled Comodo my computer rebooted and was 100% OK.

I just wanted to see if anyone else ever had the same issue…