I found that there is a problem with Comodo the latest version 5.9
it is interfering ADBOBE Reader sandboxed by Sandboxie, I posted on Sandboxie forum and it is resolved, however I thought to post this here as well.
here is the link to the thread
http://www.sandboxie.com/phpbb/viewtopic.php?t=12115
the problem is the DLL file Guard32.DLL
Merry Christmas 