I have CIS installed without the anti-virus packege and D+. I use instead Panda Cloud AV and Malwarebytes and Threatfire.
When I download and scan very good 0-day malware packages both Panda and Malwarebytes cleans most of the malware. But quite many are left undetected.
When trying to launch these files almost every file triggers an alert from Comodo Cloud AV component and the process is blocked. I think this shows how updated your cloud datebase is, it is better than Panda’s and Malwarebytes.
The rest CAV can’t find Threatfire takes care of. i think I have a very good layered defence and my machine has never been this light before!