As soon as vista sp2 was installed, my registery cleaner (clean my pc) quit working.
Having a quiet day, I rebuilt the system from scratch, vista 32 bit home premium, adding sp1 and sp2 from hard disk.
Installed clean my pc and it worked perfectly. Loaded CIS and clean-my quit working.
Restored system to before Comodo install and clean-my works once more.
Reluctantly went back to another anti-virus.
Hope this problem is soon resolved.
As a workaround you could try Comodo System Cleaner to clean your registry.
Edit: I split and moved your reply to the bug boards. This way the devs will most certainliy take notice of it.