CIS problem

Well, first of all hello. I’m not a computer expert but I know enough to manage myself. I installed COMODO CIS3 and after 1h my computer started to not act at my commands. For example I press right click and it will not open. I try to go to start>run>cmd(I hear an windows error sound and cmd doesn’t open). I try to go to my computer. My theme and drivers are changed(titles>icons). What is happening? It is a computer attack or something? How can I setup COMODO CIS to block those attacks and not get them anymore?
Please help me to configure my COMODO CIS.
Thanks very much!
Ps:I don’t have viruses or something like that. My computer was scanned with 7 Av programs.