Checking settings

What can I do if I think that my firewall is interfering with another software program as shown in this screenshot

This is a memory sharing issue, simple to resolve.

Select Defense+ -->Advanced → Computer Security Policy.
Scroll down to Comodo Internet Security, select Edit → Protection Settings.
Interprocess memory Access (Active Yes) select Modify → Add -->Now use Running Processes or Browse to point to the concerned file(s) .
Then just “Apply” to each window as you exit.

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I think that will help.