You have ESET NOD32 antivirus installed and on, do you have both the antivirus and the firewall of Comodo CIS installed?
[b]In Proactive Security mode with Defense+ in Training Mode cfp.exe uses up to 60% of cpu[/b]
This can often happen when you have more than one anti-virus/real time scanner(process explorer) running.
~edit~ 'referance for later
Also, antivirus scanners tend to try and delete each other and will often recognize each other’s virus database as a virus. One will fight to protect itself while the other keeps attempting to delete it. Basically, you’re having an antivirus fight night on your computer.
~/edit~
i.e. if you have Trend Micro Worry Free Security SMB client as well as Panda Antivirus installed, your system will slow to a crawl.
Had to disable Defense+ OR bump up to Safe Mode to quell cpu
This makes me think yes, you have conflicting real time scanners. In particular COMODO Defense+ is detecting a program scanning your files.
~edit~ bad idea suggested while half asleep~/edit~
Try adding NOD32 and all processes to the allow rules in defense+ and see what happens.