I’ve spent most of the day today trying the workarounds so that I would be able to play my games that now use Game Guard. None of them work. I still get the error message “Game Guard initialization error.
Try again after a reboot or close programs that are currently running.” I have to completely unistall Comodo so I can play my games >:(
Welcom to the forum CelticQueen 
Take a look at this thread for some help:
same problem! on Vista 32
and every settings in firewall/defense+ did not work.
Gameguard process suddenly stop so game won’t load.
The only solution is to uninstall CIS. 