I installed only antivirus module of CIS (newest version) for testing it but had a problem. My Raxco Perfect Disk 10 took 5 minutes only to analyze my 40 GB partition on Windows Vista Home Premium. I removed the antivirus and everything goes back to normal. A few seconds to analyze my HD.
Others disk defrag utilities had same issue with CAV?
What version of CIS are you using? The AV in the latest beta, 3.9, has what is termed Stateful . What this does is scan your files the first time you use an application. After that, the files are only scanned again if they have changed. You would see a performance increase the second time you ran Perfect Disk.