Comodo and Nuance Dragon Naturally Speaking just do not work together or at least they have not for a long time, when will they be compatible or is there a fix at all for this?
Hi jeffo and welcome.
Have you tried running both the firewall and defense+ in training mode for a while so that they can learn the actions of the program?
Comodo and Nuance Dragon Naturally speaking do not work at all together, there has been many discussions but still no answer, one discussion is on this forum https://forums.comodo.com/firewall_help/comodo_firewall_killed_dragon_naturally_speaking-t44600.0.html;msg322419#msg322419 basically one of the programs has to be uninstalled, it there any fix in the pipeline?
Are there any relevant entries in the firewall logs?
Are there any relevant entries in the Defense+ logs?
Is it failing during the installation or when trying to run the app?
Can you please provide the exact error messages you are recieving?
Ewen 
Have you requested help from Nuance and if yes, what did they have to say? Would be interesting to have both party looking at the problem.
I am also having this problem. When I try to start Dragon Naturally Speaking a window opens saying “Dragon NaturallySpeaking for Windows has stopped working…A problem caused the program to stop working correctly.” but it doesnt say what problem. I am running Vista SP2 and have only just installed Comodo. I will also let Nuance know…
I tried the recommendation on https://forums.comodo.com/firewall_help/comodo_firewall_killed_dragon_naturally_speaking-t44600.0.html;msg322419#msg322419 but no luck… There are no relevant entries in the firewall/Defense+ logs
I found this information on the Nuance site but adding DNS as an exception in Comodo doesnt seem to make a difference:
http://knowledgebase.nuance.com/view.asp?60VQ=KGDI&5d7r4B=51s69n4r%20p1z2n6vovyv6B
Problems caused by Anti-Virus software
Products: Dragon NaturallySpeaking 8, 9, 10
Problem:
When launching or using Dragon NaturallySpeaking, it is possible that third party Anti-Virus software may interfere with Dragon. These interferences may include dictation being blocked in Outlook, or the Anti-Virus software may show an alert that the “natspeak.exe” process is possible malware.
Cause:
Dragon NaturallySpeaking connects to applications for tracking windows, text fields and dialog boxes. This connection may be improperly detected as an intrusion by the Anti-Virus software.
Solution:
To ensure that the Anti-Virus software does not interfere with Dragon NaturallySpeaking, add the Dragon installation directory to the Anti-Virus program’s exception list.
Note: The steps for adding an exception will vary with different Anti-Virus software. Please consult the Anti-Virus program’s Help File for the exact steps on adding an exception.
The following Dragon NaturallySpeaking directories should be added as exceptions:
C:\Program Files\Nuance\NaturallySpeaking10 (Dragon NaturallySpeaking 10)
C:\Program Files\Nuance\NaturallySpeaking9 (Dragon NaturallySpeaking 9)
C:\Program Files\ScanSoft\NaturallySpeaking8 (Dragon NaturallySpeaking 8)
Note: If the Anti-Virus program asks whether to include all sub-folders and files to the exception list, select Yes.
TechNote Number: 6078
Published: 4/13/2009
Last Modified: 4/14/2009
My experience is that Comodo is not compatible with any version of Dragon Naturally Speaking and I have had to re-format 2 computers. I had to set DNS up on a stand alone computer so I can use the program, then transfer the dictated drafts over to my main computer to finish the editing process.
DNS customer support told me that COMODO has just issued a patch that corrects the problem, but I am not going to try it anytime soon unless someone has done it and can verify that it works.