Block a file with defense+ pretty much removes all permission(s) of the file so that only CIS Can Access it
Block a file with Antivirus moves the file to %programfiles%\comodo\Comodo internet security\quarantine* and removes the permissions of the file so that only CIS can access it;
Why there are two ways to do it; because if you don’t have the antivirus component you can use defense to do such thing;