There seems to be a problem where even though you set applications to be trusted or allowed, the firewall still blocks them. For example, unless you set it to be in stall mode you cannot use windows media player to watch any of the web casts at http://msdn2.microsoft.com/en-us/beginner/bb308760.aspx.
Also ever since installing version 3.0.14.276, I cannot start Civ4. The process starts then shuts down.
Even uninstalling Comodo doesn’t help with either problem. Obviously there is also an uninstall issue as well.