Virtual Box conflict.

:(Yes, I read your post requirements but before I go nuts submitting logs please define if I have to go to that route. I sometimes run Virtual Box on my Windows 7 desktop. In addition to several Linux OS’s is Windows 7 Ultimate which includes a fully functioning Comodo CIS program. If I try to install CIS on the host it generates errors 1601-1603. The only Comodo on the host is Chromodo. My question is it possible for CIS occasionally running on a virtual machine on a separate HDD, not turned on to somehow “bleed” through into the host OS preventing a host installation of CIS? I apologize for usurping your forum request and will comply if you need the requested logs.
In respect…thank you.