Userinit.exe & tucows?

I have an always on connection and I went to search my computer and a Comodo pop up said that explorer was using userinit.exe (or vice-versa) to send out to a certain ip address belonging to Tucows.com (207.46.248.249), it seemed malicious on siteadvisor so I activated block all for a short time to think

should these be connecting to the internet and if I make a rule to block these from sending out will it adversly affect my computer?