Hello,
There seems to be a typo in the Defence+ “Internet Explorer Keys” group, the “\Software\Microsoft\Internet Explorer\Menuex" key entry should be "\Software\Microsoft\Internet Explorer\Menuext”. Note the final “T” is missing from Menuext in the current default setting, as a result Defence+ is protecting a registry key that doesn’t exist!
I have tested this on 3.018.x upgraded to 3.0.20.x and both versions have this problem. It’s easy enough to change the entry in the groups dialog yourself but I have also submitted a support ticket so hopefully it will be fixed in the next release.