Tray Icon Stopped Functioning

Even though the v2 firewall is still functioning (shown in running processes), when I right-click or double left-click the tray icon, nothing happens. Similarly, Start, Programs, Comodo, Firewall click doesn’t do anything. This only just recently started happening. How can I fix this and what might have happened? If I restart, then I’m back to them functioning as they had.

Thanks!

sorry. this IS with v3. Also should have mentioned that all other tray icons for other programs can be accessed appropriately, so nothing wrong with my mouse. Am running Vista home premium and user sharing with my wife’s desktop. thanks again