It is not uncommon for legit and non legit programs to access other programs in memory. CIS by default does not allow this as a mean of self protection.
The default action of timing out is that the request will be blocked. That is the default deny principle. Apparently the SynTPhelper.exe gets upset when it cannot do its thing.
To resolve the memory access problem:
Select Defense+ -->Advanced → Computer Security Policy.
Scroll down to Comodo Internet Security, select Edit → Protection Settings.
Interprocess memory Access (Active Yes) select Modify → Add -->Now use Running Processes or Browse to point to the concerned file(s) .
Then just “Apply” to each window as you exit.
plug in an external mouse. move the touchpad. when it freezes the pointer, use the external mouse to click allow and make sure remember my answer was checked. It wont happen again