I think alot of people have their internet on 24/7… My router probably has dust on the Ethernet cable that has never been unplugged from my PC. lol
Personally I’d feel safe with just Comodo, + I also have a hardware firewall as a bonus
I agree with Commodus although he wants to sleep with his sister. I have a 2Wire Gateway DSL modem with a hardware firewall built in and its on full stealth. I can pass the Shields Up with n o software firewall. I use Comodo for the HIPS maninly. I do surf all sites and never been infected. Be sure your hardware firewall is fully stealthed. A good av like Avast or Avira Premium 8 goes along with Comodo very well. Use SAS and MBAM for on demand spyware scanners. BTW I rarely turn my pc off.
You will never be 100% safe,unless you disconnect from the net,if someone is really out to get you if they have access to the right stuff and the knowledge of how to use it they will.
All you can do is make it as tough as possible so any casual look out`s will pass you by.
At http://en.wikipedia.org/wiki/Avira I read that in January 2008 Avira AntiVir was rated 6.5 out of 8 in tests for detection and removal of rootkits and 71% for proactive virus detection by Anti-Malware Test Lab. Also it received "poor results for infection treatment and it failed the self-protection test.