several probs all at once

first prob noticed was very slow running of programs and internet site loading
second nothing shown in device manager
third system restore is empty
forth running services.msc

I get error message 

unable to open sevice control manager database on .

1722 the RPC server is unavailable   click ok twice 
                                                  [b]services local is also empty                 

however if i boot in safe mode device manager is full
if i boot normally and select defence + security disabled in comodo then again device manager is ok

what is going on here and what do I need to do to correct it

Sounds like a bad install. Do a complete uninstall and reinstall using the instructions at .