Bad Frogger gave out a good advice. (:CLP)
You could also select 'Only allow digitally signed e-mail' in the policy page of Comodo AntiSpam2.5, and please make sure do not add your own e-mail address in white list. If you want to sign e-mail you sent out, you could get one free certificate from Comodo. And Secure Email will be a good choice if you know little about certificate and digital signature.
The problem is most email senders don’t digitally sign their emails, so Ryanman may not get all his “real” emails.
What I do to help limit spam: I have two email addresses (and I view both accounts at the same time in my email reader, Windows Live Mail), one is for signing up at sites I trust (like Comodo and Microsoft), the second is for signing up at suspicious sites that might send spam.
I only check my second “spam” account when I am expecting a email.
So the result is, my first “real” account gets usually no spam, while my second “spam” account get more than 40 spam emails per day (but I don’t care).