I strongly doubt that Comodo will be able to sustain that rate. Most likely it will level off to something like 1000 sigs or lower per day.
RejZoR is right. I can’t see how Keygens and cracks can be classified as malware unless they actually act maliciously. Just the fact that they happen to be that type of software doesn’t mean that they are bad.
If you give antivirus alerts for harmless programs, when who is to say the user will not ignore the alerts for actual harmful ones?