I am running XP Media Center Edition SP3 32 bit and use CIS version 4.1.150349.920 for virus and firewall.
When executing most applications, they are run in the sandbox. Quicken Home & Business 2010 edition is no exception. I could not successfully backup my Quicken files from Quicken while running in the sandbox. Quicken could not save the file to my portable disk drive. If I ran the application outside the sandbox there was no problem.