Question about sandbox

Recently I had to remove some light malware and decided to change a bunch, I mean a bunch of passwords, as I’m sure you know all too well about.

Question is I decided to use the program Lastpass running in sandbox to change many if not all these passwords. Will having used lastpass in sandbox cause any issues when I run Lastpass and other progs/browsers outside of sandbox?

I will spend another weekend messing about with my couple pcs if need be but I hope I am good to go.

Any help etc will be much appreciated. I have the free addition but have paid for comodo in past an depending upon the answers I get I probably will up grade

Thanks, Mark