Question about Proactive Defense

Hello, I hope this is in the right place.

I have a question about the Proactive Defense section where the firewall lists files it’s unsure of for you to review. There’s an Add, Move To, Remove, Look Up, Submit and Purge button. I’m not really sure what to do here but if I just ignore it and allow the files to accumulate Comodo starts to run very sluggishly. The only time files show up there is when I install something myself so I’m not worried that they may be infected so all I’ve been doing so far is selecting them all and clicking Remove. But I don’t really know what that does because the guide doesn’t say and I’m worried it may be deleting the actual files or something like that.

So my question is is it alright to do that or should I move the files to My Safe Files instead?

Thanks very much.