possible malware or..

I have aproblem. Comodo defense recognise a file as not secure.
“…could not be recognized and it is about to modify the contents of C:\WINDOWS\Temp\B6.tmp. You must sure…”
After I block or not that message appear again and again. It count till now something 97.tmp.
How could I clean that?

Please follow the advice I give in my article about How to Know If Your Computer Is Infected and let us know what you find.