Please advise me on updates for CIS

When a new release comes out I normally just use the updater but suppose I decide to just download the install file and then install from that then will my configurations be saved or will I have to start all over again?

If you uninstall CIS and reinstall the new version your configurations will be deleted. Personally, I prefer to reinstall every time new release comes out although I lose my configurations.

Uninstalling CIS will wipe out your config too though it is possible to backup your configuration before uninstalling.

From time to time the standalone installer provide new config defaults so in such cases you have either to manually add those changes or start from scratch.

eg:
How can i migrate from CFP 3.0.x to CIS 3.5.x ?
What are the defaults for “COMODO - Internet Security” CIS 3.5.54375.427
What are the defaults for “COMODO - Internet Security” CIS 3.8.64739.471