The user needs to keep in mind that HIPS alerts in Comodo apply to the object being mentioned at the LEFT side in the alert. If they choose the option to treat as: Blocked Applications, then explorer.exe which corresponds to Windows Explorer will be blocked from running other executables and this will cause problems in the system.
I even saw a Youtube tester commit this mistake once while testing Comodo and worse of all, he initially thought that Comodo allowed an infection. In the end he had to delete his video because of this silly mistake, but the point is: If you don’t know how to properly answer HIPS alerts in Comodo, you may as well destroy your OS. So users are advised to:
a) Set HIPS to Auto-Block in HIPS settings.
b) Disable HIPS.
I really don’t see the need for all this lamentations if the user just answered a HIPS alert in the wrong way.