My Own Safe Files = Trusted Application?

Does D+ treat “My Own Safe Files” as a “Trusted Application”? What is the difference between a file under “My Own Safe Files” and a file with a “Trusted Application” policy?

They are not the same but it depends on which mode you run defence+ in. A trusted application is allowed everything except run an executable. It does not need to learn so in paranoid mode where nothing is learned automatically you will get no pop-ups. A safe application learns automatically in safe mode but not paranoid mode where you will get pop-ups. Also, if you say something is safe it will be called a safe application in the message on a pop-up.