Malware that destroys computers permanently

Macs are “more easy” targets as the hardware is common among them.
Other hardware and operation systems can be a target too.

In theory a drive by is a scenario for this irreversible danger.

Does the comodo sandbox protect against hardware code changes?
Does comodo ask for hardware code changes?

I would say that to Flash a BIOS you need to run a driver which is not allowed to unknown programs.