Defense+ does not, as far as I know, protect from BO attacks - which CMF does. It’s also important to point out that D+ and BOClean have different tasks. With D+ you can make sure that nothing malicious is executed without your awareness. However, if you allow something to execute (like a post card or whatever you’ve downloaded), and it turns out to be malicious - D+ won’t help you but hopefully BOClean will catch it!
To be secure, you should have several layers of protection. Defense+ is just one layer (prevention).
NO, Boclean and CMF have to be seen as supplements of the CFP 3.0 because their using detection technology and CFP 3.0 is a prevention solution. (correct me if I am wrong, you could see CMF as prevention…)
As for the quesion if CFP 3.0 with defense + disabeled it will give you similar protection that version 2 gives, but than you have to activate leak protection by setting the firewall to network security.