Implications of PC Rename

What are the implications of renaming a PC running Comodo Internet Security?

It would be on the same windows domain, and would continue to be assigned an IP address dynamically.

Will all the settings be lost?
Will detect it as a new network?

Is there anything that should be done or backed up before the rename?

You should not have any issues with renaming the PC and you do not need to make any changes to CIS for it to continue to work properly.