Im using Comodo Firewall v5.10 with Defense+ disabled by the setting “Deactivate the Defense+ permanently” but this is not enough, Defense+ keeps catching Trusted Files. 
I cleaned all the Trusted Files and then to test I started Firefox and Defense+ keeps catching trusted executables, WHY?
And if you want to know, my other Defense+ settings are disabled too, check this images:
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try unchecking all the boxes in the other tabs in the defense + settings.
No, does not work, check my topic, I added all my current Defense+ settings.
sounds like a bug to me
Have you tried to add it in d+ exclusion? (the box next to injections)
Yes, for me too… from Comodo Firewall version 4 it happening this problem, with Comodo Firewall version 3 was working perfect.
I tried a lot of different settings and doesnt work but I cant find the setting that you are saying, dont know what to add to exclusion.
CIS → d+ → d+ settings → execution control settings -->exclusion (next to detect shellcode …)
No, doesnt work, tried excluding Comodo group of executables and all the .exe files but does nothing, all the programs that I run are cached in the Trusted Files. >:(
what are you telling DarkBlood to exclude? he is trying to disable defense +
So that CIS doesn’t control or monitor the wanted files.