Certainly so; there’s no way Comodo can catalog every program or signer in the world.
I keep the Firewall set to Custom Policy so I set rules on what every executable can and can’t access on the network. I’m not sure how the other modes work exactly, but surely you can add in a program and set specific rules for it (like “allow everything”). I don’t use the Defense+ part much either, but surely there’s the same kinda of setup there.
Sorry I don’t have a copy of v6 in front of me or I’d help get you started.
I made a video going through how to allow a folder for HIPS and Firewall and exclude it from sandboxing, video is here: Allow a folder for HIPS, BB and Firewall in CIS - YouTube (might still be processing, give it a minute or two)