how do you initialize the antivirus engine

the attach file pops up when trying to run a virus scan

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What is your OS and do you have DEP enabled?

Does this FAQ article help you: https://forums.comodo.com/anti_virus_faq/antivirus_engine_not_initializedcorrupt_virus_data_base-t32072.0.html ?

My os is vista and dep is on… To fix the problem I went ahead and reinstalled cis 3.8 and everything seems to be running fine now…

thanks for the reply ericjh

Is DEP monitoring all programs and services? If so, you might want to disable DEP for cmdagent.exe
See here: https://forums.comodo.com/anti_virus_help/av_scans_freeze_what_to_do-t36580.0.html

Although this talks about scan freezes, the ‘AV not initialized’ problem can be related to DEP.