I have been doing some testing on the ability of CIS to clean a infected computer. What I have been doing is infecting the pc and then installing comodo.
First off it needs to protect the install, I have had many times when the malware would stop CIS from installing. Other AV companies have install protection, this needs to be added.
Second, it needs to have the ability to remove files on reboot. I had a root kit that it found but because it was active CIS could not remove it. There needs the ability to remove infected files on reboot.
Thirdly it needs that ability to reapir patched windows files. I had a TDSS rootkit that patched a windows driver and CIS could not do anything about it.
Fourth is that any files that is quarantined by comodo needs to be packed and encrypted so there is no chance for it to get out. This will do two things, by packing it, it will be smaller when you want to submit the file and by encrypting it, as we all know windows files are never gone they are still on the hard drive and there is always a change to find them again. Encryption stops the chance of a file from reinfecting your pc.
I think these three additions alone could really make comodo much more capable at fixing an infected PC.
Comprehensive Comodo ‘GeekScan’ could be a much improved option to using the time and resource consuming combination of half a dozen different on demand Malware scanners that is usually recommended here on the Forum in order to get definitive results!
the best two cleaners in my opinion is Dr. Web and Kaspersky.
EDIT: there are two reasons they are the best. They have very good signatures ( incorporating what I said in the first post) and they have a liveCD linux based scanner that can clean out everything they detect.