Hi, I am using Outlook Express and I get the following message: Error Number: 0x800CCC19
I think it’s a problem with my AntiVirus Comodo IS.
Can somebody help me ? 
A quick look on Google shows that 0x800CCC19 is a timeout error. Here is Microsoft’s recommend steps to resolve the issue: Error occurs when you send or receive an email message in Outlook or Outlook Express - Microsoft Support
Are you using the full CIS with firewall as well? Are you getting any alerts from Comodo about Internet connection requests? What are your Email settings i.e. POP3, IMAPI. And who is your mail email provider?