Did you update the ALLOW REGKEY?

Comodo Internet Security - CIS Install / Setup / Configuration Help - CIS
#1

According to this: January 3, 2018—KB4056892 (OS Build 16299.192) - Microsoft Support


Contact your Anti-Virus AV to confirm that their software is compatible and have set the following  REGKEY on the machine
Key="HKEY_LOCAL_MACHINE"Subkey="SOFTWARE\Microsoft\Windows\CurrentVersion\QualityCompat"
Value Name="cadca5fe-87d3-4b96-b7fb-a231484277cc"
Type="REG_DWORD”
Data="0x00000000”
#2

https://forums.comodo.com/news-announcements-feedback-cis/does-cfw-interfere-with-the-meltdown-patch-t121297.0.html;msg870972#msg870972