Defense+ will not allow X-fire and Medal of Honor to run together

I am having a problem with defense+. If I run X-Fire there is no problem, If I run Medal of Honor MP, there is no problem.

However if I run X-Fire and then run Medal of Honor, the game starts to load and then crashes.

If I look at the Defense+ logs it shows the following (paths shortened to show affected files only)

                             [u]Application[/u]                 [u]Flag[/u]                  [u]Target[/u]

2010-11-21 22:36:51 MoHMPGame.exe Access Memory cmdagent.exe

If I try to add it as a trusted program it says that it already is!

I have tried the advice posted here: https://forums.comodo.com/defense-sandbox-faq-cis/access-memory-event-log-entries-how-can-i-suppress-these-v5-t61745.0.html but the same still happens.

If I start the game without X-Fire running, it runs fine , with no alerts.

Any help gratefully recieved.