VGI
#1
https://forums.comodo.com/defense_help/usb_disk_security_as_trusted_app_ignored_by_proactive_defense-t37207.0.html;msg264634#msg264634
In the above link, I made my debut in the COMODO forums. The problem was nicely resolved. Unfortunately, the problem is back.
I re-did the solution posted in the above link and found that USBGuard.exe was NOT in the Exception window, so I promptly put it back there.
I re-did all the steps in the solution…nothing. The list “The Defense+ has blocked **** suspicious attempts so far” is in the thousand.
I need further help. 
Are you getting the same alerts? Please double check you did the steps as described by Matty_R.
Can you show a screenshot of the D+ logs?
VGI
#3
I’ll try a fresh re-install of the latest CIS. If still it doesn’t work, then I’d consider posting pics.