Defense+ blocking safe application

So I play an online game - completely safe - that Comodo shut down the first time it started. I put it in my safe files, and assumed this would be the end of the problems. However, it refused to allow the game to start again. I looked in Comodo and was greeted by a message informing me 883, all the same (2010-08-10 22:18:30 C:\Riot Games\League of Legends\game\League of Legends.exe Direct Keyboard Access ), threats had been blocked.

This is fairly frustrating, as I’m not sure what else I can do besides lowering the defense level (Set to Clean PC). Any help with stopping these messages and getting the game to work is appreciated!

Is the game vendor in the ‘My Trusted Software Vendors’ list?

Delete any rules for it from the Defense+ ‘Computer Security Policy’.

Set Defense + to Training Mode and start the game. Play with it for several minutes, close down the game and set D+ back to its previous setting. Only do this when you are sure your system is free from malware. In Training Mode CIS will learn all the rules for all programs without notifying the user.